Cargando…

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like

BACKGROUND: Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saito, Yuhki, Akiyama, Mayu, Araki, Yoichi, Sumioka, Akio, Shiono, Maki, Taru, Hidenori, Nakaya, Tadashi, Yamamoto, Tohru, Suzuki, Toshiharu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139598/ https://www.ncbi.nlm.nih.gov/pubmed/21818298 http://dx.doi.org/10.1371/journal.pone.0022108

Ejemplares similares

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
por: Kondo, Maho, et al.
Publicado: (2010)

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport
por: Chiba, Kyoko, et al.
Publicado: (2014)

The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
por: Yang, Miao, et al.
Publicado: (2013)

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
por: Tang, Bor Luen
Publicado: (2019)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
por: Piao, Yi, et al.
Publicado: (2013)

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles
por: Groemer, Teja W., et al.
Publicado: (2011)

Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity
por: Schilling, Sandra, et al.
Publicado: (2023)

Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1
por: Chiba, Kyoko, et al.
Publicado: (2017)

Upregulation of PGC-1α expression by Alzheimer’s disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
por: Robinson, Ari, et al.
Publicado: (2014)

β-Amyloid precursor protein (APP) and the human diseases
por: Nguyen, Khue Vu
Publicado: (2019)

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development
por: Ramaker, Jenna M., et al.
Publicado: (2016)

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway
por: Tam, Joshua H. K., et al.
Publicado: (2016)

Role of amyloid precursor protein (APP) in regulation of neuronal genes
por: Nalivaeva, Natalia N.
Publicado: (2015)

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
por: Mockett, Bruce G., et al.
Publicado: (2017)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Pharmacological targeting of the β-amyloid precursor protein intracellular domain
por: Branca, Caterina, et al.
Publicado: (2014)

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
por: Brodeur, Julie, et al.
Publicado: (2012)

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles
por: Cone, Allaura S., et al.
Publicado: (2020)

Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know?
por: Lin, Tong, et al.
Publicado: (2021)

Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)
por: Coburger, Ina, et al.
Publicado: (2013)

Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
por: Lee, Han Na, et al.
Publicado: (2021)

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation
por: Edgar, James R., et al.
Publicado: (2015)

Novel Adaptors of Amyloid Precursor Protein Intracellular Domain and Their Functional Implications
por: Chakrabarti, Arunabha, et al.
Publicado: (2012)

Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein
por: Seita, Yasunari, et al.
Publicado: (2020)

O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production
por: Tachida, Yuriko, et al.
Publicado: (2023)

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production
por: Tan, Jing Zhi A., et al.
Publicado: (2020)

The Alzheimer Amyloid Precursor Protein (APP) and Fe65, an APP-Binding Protein, Regulate Cell Movement
por: Sabo, Shasta L., et al.
Publicado: (2001)

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
por: Menon, Preeti Kumaran, et al.
Publicado: (2019)

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
Publicado: (1995)

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
por: Zerbinatti, Celina V, et al.
Publicado: (2008)

Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
por: Cam, Judy A, et al.
Publicado: (2006)

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies
por: Hermey, Guido
Publicado: (2015)

Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model
por: Shen, Qi, et al.
Publicado: (2022)

APP intracellular domain/WAVE1 pathway reduces amyloid β production
por: Ceglia, Ilaria, et al.
Publicado: (2015)

Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing
por: Liu, Chia-Chen, et al.
Publicado: (2012)

Effects of Gene Imbalance on Amyloid Precursor Protein [APP] Expression in Grafts and Recipient Cortex
por: Hohmann, C. F., et al.
Publicado: (1992)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
por: Jung, Joo In, et al.
Publicado: (2014)

Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human Cells
por: Sobol, Anna, et al.
Publicado: (2015)

Transcriptional and Post-Transcriptional Regulations of Amyloid-β Precursor Protein (APP) mRNA
por: Sato, Kaoru, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r48e5stcgf6rguqru5k60l86su