ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions

We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical so...

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Detalles Bibliográficos
Autores principales: Bevc, Staš, Konc, Janez, Stojan, Jure, Hodošček, Milan, Penca, Matej, Praprotnik, Matej, Janežič, Dušanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139599/
https://www.ncbi.nlm.nih.gov/pubmed/21818304
http://dx.doi.org/10.1371/journal.pone.0022265
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author Bevc, Staš
Konc, Janez
Stojan, Jure
Hodošček, Milan
Penca, Matej
Praprotnik, Matej
Janežič, Dušanka
author_facet Bevc, Staš
Konc, Janez
Stojan, Jure
Hodošček, Milan
Penca, Matej
Praprotnik, Matej
Janežič, Dušanka
author_sort Bevc, Staš
collection PubMed
description We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be used for routine tests in enzyme kinetics. It is freely available as a web tool, at http://enzo.cmm.ki.si.
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spelling pubmed-31395992011-08-04 ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions Bevc, Staš Konc, Janez Stojan, Jure Hodošček, Milan Penca, Matej Praprotnik, Matej Janežič, Dušanka PLoS One Research Article We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be used for routine tests in enzyme kinetics. It is freely available as a web tool, at http://enzo.cmm.ki.si. Public Library of Science 2011-07-19 /pmc/articles/PMC3139599/ /pubmed/21818304 http://dx.doi.org/10.1371/journal.pone.0022265 Text en Bevc et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bevc, Staš
Konc, Janez
Stojan, Jure
Hodošček, Milan
Penca, Matej
Praprotnik, Matej
Janežič, Dušanka
ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title_full ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title_fullStr ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title_full_unstemmed ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title_short ENZO: A Web Tool for Derivation and Evaluation of Kinetic Models of Enzyme Catalyzed Reactions
title_sort enzo: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139599/
https://www.ncbi.nlm.nih.gov/pubmed/21818304
http://dx.doi.org/10.1371/journal.pone.0022265
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