Cargando…

Location-Specific Epigenetic Regulation of the Metallothionein 3 Gene in Esophageal Adenocarcinomas

BACKGROUND: Metallothionein 3 (MT3) maintains intracellular metal homeostasis and protects against reactive oxygen species (ROS)-induced DNA damage. In this study, we investigated the epigenetic alterations and gene expression of the MT3 gene in esophageal adenocarcinomas (EACs). METHODS AND RESULTS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, DunFa, Hu, Tian-Ling, Jiang, Aixiang, Washington, Mary Kay, Moskaluk, Christopher A., Schneider-Stock, Regine, El-Rifai, Wael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139601/ https://www.ncbi.nlm.nih.gov/pubmed/21818286 http://dx.doi.org/10.1371/journal.pone.0022009

Ejemplares similares

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas
por: Peng, DunFa, et al.
Publicado: (2017)

Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis
por: Ballout, Farah, et al.
Publicado: (2022)

Regulation of Desmocollin3 Expression by Promoter Hypermethylation is Associated with Advanced Esophageal Adenocarcinomas
por: Wang, Qinggang, et al.
Publicado: (2014)

APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts
por: Hong, Jun, et al.
Publicado: (2016)

Unfolded Protein Response Is Activated by Aurora Kinase A in Esophageal Adenocarcinoma
por: Lu, Heng, et al.
Publicado: (2022)

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
por: Zhou, Zhangjian, et al.
Publicado: (2019)

Co-overexpression of AXL and c-ABL predicts a poor prognosis in esophageal adenocarcinoma and promotes cancer cell survival
por: Hong, Jun, et al.
Publicado: (2020)

Deciphering the Unique MicroRNA Signature in Human Esophageal Adenocarcinoma
por: Saad, Rama, et al.
Publicado: (2013)

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells
por: Sriramajayam, Kannappan, et al.
Publicado: (2021)

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
por: Gomaa, Ahmed, et al.
Publicado: (2019)

Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma
por: Islam, Md Obaidul, et al.
Publicado: (2023)

APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
por: Ballout, Farah, et al.
Publicado: (2022)

Targeted Molecular Therapies in the Treatment of Esophageal Adenocarcinoma, Are We There Yet?
por: Khalafi, Shayan, et al.
Publicado: (2020)

Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
por: Zhu, Shoumin, et al.
Publicado: (2019)

The antioxidant response in Barrett's tumorigenesis: A double-edged sword
por: Peng, Dunfa, et al.
Publicado: (2021)

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
por: Coyle, P, et al.
Publicado: (2002)

Silencing of Glutathione Peroxidase 3 through DNA Hypermethylation Is Associated with Lymph Node Metastasis in Gastric Carcinomas
por: Peng, Dun-Fa, et al.
Publicado: (2012)

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus
por: Chen, Lei, et al.
Publicado: (2023)

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis
por: Peng, Dun-Fa, et al.
Publicado: (2014)

Activation of NADPH oxidases leads to DNA damage in esophageal cells
por: Bhardwaj, Vikas, et al.
Publicado: (2017)

Advances in targeted therapies and new promising targets in esophageal cancer
por: Belkhiri, Abbes, et al.
Publicado: (2015)

N-MYC Downstream Regulated Gene 4 (NDRG4), a Frequent Downregulated Gene through DNA Hypermethylation, plays a Tumor Suppressive Role in Esophageal Adenocarcinoma
por: Cao, Longlong, et al.
Publicado: (2020)

Epigenetic Alterations from Barrett’s Esophagus to Esophageal Adenocarcinoma
por: Ergun, Pelin, et al.
Publicado: (2023)

Mammalian Metallothionein-2A and Oxidative Stress
por: Ling, Xue-Bin, et al.
Publicado: (2016)

Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma
por: Taylor, Chase, et al.
Publicado: (2015)

Exposure of Barrett’s and esophageal adenocarcinoma cells to Bile acids activates EGFR-STAT3 signaling axis via induction of APE1
por: Bhat, Ajaz A., et al.
Publicado: (2018)

t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
por: Vangamudi, Bhavatarini, et al.
Publicado: (2010)

Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer
por: Chen, Zheng, et al.
Publicado: (2017)

Proinflammatory Cytokines and Bile Acids Upregulate ΔNp73 Protein, an Inhibitor of p53 and p73 Tumor Suppressors
por: Zaika, Elena, et al.
Publicado: (2013)

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
por: Soutto, Mohammed, et al.
Publicado: (2019)

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling
por: Alvarez-Trotta, Annamil, et al.
Publicado: (2020)

Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis
por: Mohamed, Mona M., et al.
Publicado: (2014)

Correlation of the location of superficial Barrett’s esophageal adenocarcinoma (s-BEA) with the direction of gastroesophageal reflux
por: Omae, Masami, et al.
Publicado: (2016)

Structure of mammalian metallothionein.
por: Kägi, J H, et al.
Publicado: (1984)

The roles of metallothioneins in carcinogenesis
por: Si, Manfei, et al.
Publicado: (2018)

Metallothionein in Brain Disorders
por: Juárez-Rebollar, Daniel, et al.
Publicado: (2017)

Epigenetic Regulation of p21(cip1/waf1) in Human Cancer
por: Ocker, Matthias, et al.
Publicado: (2019)

Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease
por: Russo, A J
Publicado: (2009)

Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett’s esophagus
por: Pinto, Rita, et al.
Publicado: (2022)

Voltammetric Methods in Metallothionein Research
por: Šestáková, Ivana, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_g96q4pgq18l0o43oujpv9g07fa