Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes

HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental...

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Autores principales: Ataíde, Ricardo, Mwapasa, Victor, Molyneux, Malcolm E., Meshnick, Steven R., Rogerson, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139654/
https://www.ncbi.nlm.nih.gov/pubmed/21811621
http://dx.doi.org/10.1371/journal.pone.0022491
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author Ataíde, Ricardo
Mwapasa, Victor
Molyneux, Malcolm E.
Meshnick, Steven R.
Rogerson, Stephen J.
author_facet Ataíde, Ricardo
Mwapasa, Victor
Molyneux, Malcolm E.
Meshnick, Steven R.
Rogerson, Stephen J.
author_sort Ataíde, Ricardo
collection PubMed
description HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not. Phagocytic antibodies to CS2(VSA) are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity.
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spelling pubmed-31396542011-08-02 Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes Ataíde, Ricardo Mwapasa, Victor Molyneux, Malcolm E. Meshnick, Steven R. Rogerson, Stephen J. PLoS One Research Article HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2(VSA) were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2(VSA) did not. Phagocytic antibodies to CS2(VSA) are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identification of correlates of immunity. Public Library of Science 2011-07-19 /pmc/articles/PMC3139654/ /pubmed/21811621 http://dx.doi.org/10.1371/journal.pone.0022491 Text en Ataíde et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ataíde, Ricardo
Mwapasa, Victor
Molyneux, Malcolm E.
Meshnick, Steven R.
Rogerson, Stephen J.
Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title_full Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title_fullStr Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title_full_unstemmed Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title_short Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
title_sort antibodies that induce phagocytosis of malaria infected erythrocytes: effect of hiv infection and correlation with clinical outcomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139654/
https://www.ncbi.nlm.nih.gov/pubmed/21811621
http://dx.doi.org/10.1371/journal.pone.0022491
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