Cargando…

Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same?

Thus far, none of the preclinically successful and promising immunomodulatory agents for type 1 diabetes mellitus (T1DM) has conferred stable, long-term insulin independence to diabetic patients. The majority of these immunomodulators are humanised antibodies that target immune cells or cytokines. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phillips, Brett, Trucco, Massimo, Giannoukakis, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139873/ https://www.ncbi.nlm.nih.gov/pubmed/21785616 http://dx.doi.org/10.1155/2011/432016

Ejemplares similares

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients
por: Giannoukakis, Nick, et al.
Publicado: (2011)

Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease
por: Phillips, Brett Eugene, et al.
Publicado: (2017)

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice
por: Garciafigueroa, Yesica, et al.
Publicado: (2021)

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy
por: Phillips, Brett Eugene, et al.
Publicado: (2019)

Co-Stimulation-Impaired Bone Marrow-Derived Dendritic Cells Prevent Dextran Sodium Sulfate-Induced Colitis in Mice
por: Engman, Carl, et al.
Publicado: (2018)

Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice
por: Di Caro, Valentina, et al.
Publicado: (2014)

Forget the internet - log on to the Grid. Huge leap in cyber evolution
por: Cook, H
Publicado: (2003)

One more leap
por: Kwon, Jung-Hwan
Publicado: (2019)

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation
por: Phillips, Brett E., et al.
Publicado: (2021)

Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist
por: Phillips, Brett E., et al.
Publicado: (2022)

It’s Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
por: Creusot, Rémi J., et al.
Publicado: (2014)

Uncoupling hepatic insulin resistance – hepatic inflammation to improve insulin sensitivity and to prevent impaired metabolism-associated fatty liver disease in type 2 diabetes
por: Niranjan, Sitara, et al.
Publicado: (2023)

Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes
por: Petrelli, Alessandra, et al.
Publicado: (2021)

Leap into poetry : more ABC's of poetry
por: Harley, Avis
Publicado: (2001)

Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches
por: Giannoukakis, Nick, et al.
Publicado: (2023)

Response to Comment on Pietropaolo et al. Incidence of an Insulin-Requiring Hyperglycemic Syndrome in SARS-CoV-2– Infected Young Individuals: Is It Type 1 Diabetes? Diabetes 2022;71:2656–2663
por: Pietropaolo, Massimo, et al.
Publicado: (2022)

Incidence of an Insulin-Requiring Hyperglycemic Syndrome in SARS-CoV-2–Infected Young Individuals: Is It Type 1 Diabetes?
por: Pietropaolo, Massimo, et al.
Publicado: (2022)

J‐LEAPS peptide and LEAPS dendritic cell vaccines
por: Rosenthal, Ken S., et al.
Publicado: (2012)

Tolerogenic dendritic cells in type 1 diabetes: no longer a concept
por: Giannoukakis, Nick
Publicado: (2023)

LEAP LEAR
Publicado: (1996)

Leaps in genetics
por: Damle, S. G.
Publicado: (2010)

Quantum leaps
por: Bernstein, Jeremy
Publicado: (2009)

Nanomaterials: small particles show huge possibilities for cancer immunotherapy
por: Chen, Ziyin, et al.
Publicado: (2022)

Digital medicine: the next big leap advancing cardiovascular science
por: Kharlamov, Alexander, et al.
Publicado: (2023)

The quantum leap in therapeutics for advanced ALK+ non-small cell lung cancer and pursuit to cure with precision medicine
por: Itchins, Malinda, et al.
Publicado: (2022)

Profile of mood states-12: same validity, more usability
por: Pereira, A. T., et al.
Publicado: (2023)

Leap motion for developers
por: Nandy, Abhishek
Publicado: (2016)

LEP's leap forward
por: Altarelli, Guido
Publicado: (1989)

The Leap of Your Life
por: Baker, Tommy
Publicado: (2019)

Quantum Leap Year
por: Witty, Nancy
Publicado: (2013)

Ready for the next leap
por: Patwardhan, Bhushan
Publicado: (2015)

The Leaping Ague of Angus
Publicado: (1829)

Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes
por: Petrelli, Alessandra, et al.
Publicado: (2021)

State increment dynamic programming
por: Larson, Robert Edward
Publicado: (1968)

Current Advances in Immunotherapy for Glioblastoma
por: Mende, Abigail L., et al.
Publicado: (2021)

New antidepressants or more of the same?
por: Pinder, Roger M
Publicado: (2007)

Change is just more of the same
por: Abdullah, BJJ, et al.
Publicado: (2008)

Brain aging: more of the same!?
por: Vinke, Elisabeth J., et al.
Publicado: (2019)

The Future of Ageing: not more of the same
por: Sikora, Ewa, et al.
Publicado: (2017)

More or Less the Same, but Better
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_ru8lbgc8rq1sqi5o3j9855je61