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Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find ou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139959/ https://www.ncbi.nlm.nih.gov/pubmed/19752167 http://dx.doi.org/10.1093/ecam/nep135 |
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author | Varma, Astha Padh, Harish Shrivastava, Neeta |
author_facet | Varma, Astha Padh, Harish Shrivastava, Neeta |
author_sort | Varma, Astha |
collection | PubMed |
description | Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent. |
format | Online Article Text |
id | pubmed-3139959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31399592011-07-22 Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon Varma, Astha Padh, Harish Shrivastava, Neeta Evid Based Complement Alternat Med Review Article Plant-derived natural products occupy an important position in the area of cancer chemotherapy. Molecules such as vincristine, vinblastine, paclitaxel, camptothecin derivatives, epipodophyllotoxin, and so forth, are invaluable contributions of nature to modern medicine. However, the quest to find out novel therapeutic compounds for cancer treatment and management is a never-ending venture; and diverse plant species are persistently being studied for identification of prospective anticancer agents. In this regard, Andrographis paniculata Nees, a well-known plant of Indian and Chinese traditional system of medicines, has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer potential in various investigations around the globe. In vitro studies demonstrate the capability of the compound of inducing cell-cycle arrest and apoptosis in a variety of cancer cells at different concentrations. Andrographolide also shows potent immunomodulatory and anti-angiogenic activities in tumorous tissues. Synthetic analogues of the compound have also been created and analyzed, which have also shown similar activities. Although it is too early to predict its future in cancer chemotherapy, the prologue strongly recommends further research on this molecule to assess its potential as a prospective anticancer agent. Hindawi Publishing Corporation 2011 2011-02-10 /pmc/articles/PMC3139959/ /pubmed/19752167 http://dx.doi.org/10.1093/ecam/nep135 Text en Copyright © 2011 Astha Varma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Varma, Astha Padh, Harish Shrivastava, Neeta Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title | Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title_full | Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title_fullStr | Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title_full_unstemmed | Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title_short | Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon |
title_sort | andrographolide: a new plant-derived antineoplastic entity on horizon |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139959/ https://www.ncbi.nlm.nih.gov/pubmed/19752167 http://dx.doi.org/10.1093/ecam/nep135 |
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