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Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)

Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well....

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Autores principales: Aiello, Anna, Fattorusso, Ernesto, Menna, Marialuisa, Vitalone, Rocco, Schröder, Heinz C., Müller, Werner E. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983/
https://www.ncbi.nlm.nih.gov/pubmed/18996940
http://dx.doi.org/10.1093/ecam/nen072
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author Aiello, Anna
Fattorusso, Ernesto
Menna, Marialuisa
Vitalone, Rocco
Schröder, Heinz C.
Müller, Werner E. G.
author_facet Aiello, Anna
Fattorusso, Ernesto
Menna, Marialuisa
Vitalone, Rocco
Schröder, Heinz C.
Müller, Werner E. G.
author_sort Aiello, Anna
collection PubMed
description Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.
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spelling pubmed-31399832011-07-26 Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. Evid Based Complement Alternat Med Original Article Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives. Hindawi Publishing Corporation 2011 2010-09-15 /pmc/articles/PMC3139983/ /pubmed/18996940 http://dx.doi.org/10.1093/ecam/nen072 Text en Copyright © 2011 Anna Aiello et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Aiello, Anna
Fattorusso, Ernesto
Menna, Marialuisa
Vitalone, Rocco
Schröder, Heinz C.
Müller, Werner E. G.
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title_full Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title_fullStr Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title_full_unstemmed Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title_short Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
title_sort mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983/
https://www.ncbi.nlm.nih.gov/pubmed/18996940
http://dx.doi.org/10.1093/ecam/nen072
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