Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranu...

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Autores principales: Ranjith, M. S., Ranjitsingh, A. J. A., Shankar, S. Gokul, Vijayalaksmi, G. S., Deepa, K., Babu, K., Sidhu, Harcharan Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140120/
https://www.ncbi.nlm.nih.gov/pubmed/21808531
http://dx.doi.org/10.4103/0974-8490.60581
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author Ranjith, M. S.
Ranjitsingh, A. J. A.
Shankar, S. Gokul
Vijayalaksmi, G. S.
Deepa, K.
Babu, K.
Sidhu, Harcharan Singh
author_facet Ranjith, M. S.
Ranjitsingh, A. J. A.
Shankar, S. Gokul
Vijayalaksmi, G. S.
Deepa, K.
Babu, K.
Sidhu, Harcharan Singh
author_sort Ranjith, M. S.
collection PubMed
description Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.
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spelling pubmed-31401202011-08-01 Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins Ranjith, M. S. Ranjitsingh, A. J. A. Shankar, S. Gokul Vijayalaksmi, G. S. Deepa, K. Babu, K. Sidhu, Harcharan Singh Pharmacognosy Res Original Article Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats. Medknow Publications Pvt Ltd 2010 /pmc/articles/PMC3140120/ /pubmed/21808531 http://dx.doi.org/10.4103/0974-8490.60581 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ranjith, M. S.
Ranjitsingh, A. J. A.
Shankar, S. Gokul
Vijayalaksmi, G. S.
Deepa, K.
Babu, K.
Sidhu, Harcharan Singh
Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title_full Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title_fullStr Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title_full_unstemmed Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title_short Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
title_sort solanum trilobatum in the management of atopy: through inhibition of mast cell degranulation and moderation of release of interleukins
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140120/
https://www.ncbi.nlm.nih.gov/pubmed/21808531
http://dx.doi.org/10.4103/0974-8490.60581
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