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Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecuti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140143/ https://www.ncbi.nlm.nih.gov/pubmed/21808431 http://dx.doi.org/10.4103/2589-0557.68995 |
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author | Grima, Pierfrancesco Zizza, Antonella Guido, Marcello Tundo, Paolo Chiavaroli, Roberto |
author_facet | Grima, Pierfrancesco Zizza, Antonella Guido, Marcello Tundo, Paolo Chiavaroli, Roberto |
author_sort | Grima, Pierfrancesco |
collection | PubMed |
description | PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe. RESULTS: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01–1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P–1.51; P<0.01) were independent factors associated with IARI. CONCLUSION: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients. |
format | Online Article Text |
id | pubmed-3140143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31401432011-08-01 Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy Grima, Pierfrancesco Zizza, Antonella Guido, Marcello Tundo, Paolo Chiavaroli, Roberto Indian J Sex Transm Dis AIDS Original Article PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe. RESULTS: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01–1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P–1.51; P<0.01) were independent factors associated with IARI. CONCLUSION: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients. Medknow Publications 2010 /pmc/articles/PMC3140143/ /pubmed/21808431 http://dx.doi.org/10.4103/2589-0557.68995 Text en © Indian Journal of Sexually Transmitted Diseases and AIDS http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Grima, Pierfrancesco Zizza, Antonella Guido, Marcello Tundo, Paolo Chiavaroli, Roberto Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title | Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title_full | Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title_fullStr | Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title_full_unstemmed | Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title_short | Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy |
title_sort | association of visceral adiposity with increased intrarenal artery resistive index in hiv-1-infected patients receiving highly active antiretroviral therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140143/ https://www.ncbi.nlm.nih.gov/pubmed/21808431 http://dx.doi.org/10.4103/2589-0557.68995 |
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