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Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy

PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecuti...

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Autores principales: Grima, Pierfrancesco, Zizza, Antonella, Guido, Marcello, Tundo, Paolo, Chiavaroli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140143/
https://www.ncbi.nlm.nih.gov/pubmed/21808431
http://dx.doi.org/10.4103/2589-0557.68995
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author Grima, Pierfrancesco
Zizza, Antonella
Guido, Marcello
Tundo, Paolo
Chiavaroli, Roberto
author_facet Grima, Pierfrancesco
Zizza, Antonella
Guido, Marcello
Tundo, Paolo
Chiavaroli, Roberto
author_sort Grima, Pierfrancesco
collection PubMed
description PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe. RESULTS: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01–1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P–1.51; P<0.01) were independent factors associated with IARI. CONCLUSION: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients.
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spelling pubmed-31401432011-08-01 Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy Grima, Pierfrancesco Zizza, Antonella Guido, Marcello Tundo, Paolo Chiavaroli, Roberto Indian J Sex Transm Dis AIDS Original Article PURPOSE: The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to kidney function and intrarenal artery resistive index (IARI) in human immunodeficiency virus (HIV)-1-infected patients. MATERIALS AND METHODS: We enrolled 102 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months in a prospective cohort study. Echographically, the PRFT and IARI were measured and the serum metabolic parameters were evaluated. PRFT and IARI were measured using a 3.75 MHz convex linear probe. RESULTS: The mean of PRFT and IARI in HIV-1-infected patients with visceral obesity was considerably higher than that in patients without it (P <0.001 and <0.01, respectively). Using the average IARI as the dependent variable, age (odds ratio, 1.07; 95% confidence interval [CI], 1.01–1.14; P < 0.5) and PRFT (odds ratio, 1.28; 95% CI, 1.08P–1.51; P<0.01) were independent factors associated with IARI. CONCLUSION: Our data indicate that ultrasonographic assessment of PRFT may have a potential to be a marker of increased endothelial damage with specific involvement of the renal vascular district in HIV-1-infected patients. Medknow Publications 2010 /pmc/articles/PMC3140143/ /pubmed/21808431 http://dx.doi.org/10.4103/2589-0557.68995 Text en © Indian Journal of Sexually Transmitted Diseases and AIDS http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Grima, Pierfrancesco
Zizza, Antonella
Guido, Marcello
Tundo, Paolo
Chiavaroli, Roberto
Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title_full Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title_fullStr Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title_full_unstemmed Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title_short Association of visceral adiposity with increased intrarenal artery resistive index in HIV-1-infected patients receiving highly active antiretroviral therapy
title_sort association of visceral adiposity with increased intrarenal artery resistive index in hiv-1-infected patients receiving highly active antiretroviral therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140143/
https://www.ncbi.nlm.nih.gov/pubmed/21808431
http://dx.doi.org/10.4103/2589-0557.68995
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