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Control of regulatory T cell and T(h)17 cell differentiation by inhibitory helix-loop-helix protein Id3

The molecular mechanisms directing Foxp3 gene transcription in CD4(+) T cells remain ill defined. We show that deletion of the inhibitory helix-loop-helix (HLH) protein Id3 results in defective Foxp3(+) T(reg) cell generation. We identified two transforming grothw factor-β1 (TGF-β1)-dependent mechan...

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Detalles Bibliográficos
Autores principales:	Maruyama, Takashi, Li, Jun, Vaque, Jose P., Konkel, Joanne E., Wang, Weifeng, Zhang, Baojun, Zhang, Pin, Zamarron, Brian, Yu, Dongyang, Wu, Yuntao, Zhuang, Yuan, Gutkind, J. Silvio, Chen, WanJun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140164/ https://www.ncbi.nlm.nih.gov/pubmed/21131965 http://dx.doi.org/10.1038/ni.1965

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