Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method

Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a templa...

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Detalles Bibliográficos
Autores principales: Messaoudi, Abdelmonaem, Belguith, Hatem, Ben Hamida, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140413/
https://www.ncbi.nlm.nih.gov/pubmed/21792274
http://dx.doi.org/10.4137/EBO.S7122
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author Messaoudi, Abdelmonaem
Belguith, Hatem
Ben Hamida, Jeannette
author_facet Messaoudi, Abdelmonaem
Belguith, Hatem
Ben Hamida, Jeannette
author_sort Messaoudi, Abdelmonaem
collection PubMed
description Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a template for model building. This model was then assessed for stereochemical quality and side chain environment. Natural substrates: tributyrin, trioctanoin and triolen were docked into the model to investigate ligand-substrate interaction.
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spelling pubmed-31404132011-07-26 Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method Messaoudi, Abdelmonaem Belguith, Hatem Ben Hamida, Jeannette Evol Bioinform Online Original Research Triacylglycerol lipases have been thoroughly characterized in mammals and microorganisms. By contrast, very little is known about plant lipases. In this investigation, a homology model of Arabidopsis thaliana lipase (NP_179126) was constructed using a human gastric lipase (PDB ID: 1HLG), as a template for model building. This model was then assessed for stereochemical quality and side chain environment. Natural substrates: tributyrin, trioctanoin and triolen were docked into the model to investigate ligand-substrate interaction. Libertas Academica 2011-06-28 /pmc/articles/PMC3140413/ /pubmed/21792274 http://dx.doi.org/10.4137/EBO.S7122 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Messaoudi, Abdelmonaem
Belguith, Hatem
Ben Hamida, Jeannette
Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title_full Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title_fullStr Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title_full_unstemmed Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title_short Three-Dimensional Structure of Arabidopsis thaliana Lipase Predicted by Homology Modeling Method
title_sort three-dimensional structure of arabidopsis thaliana lipase predicted by homology modeling method
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140413/
https://www.ncbi.nlm.nih.gov/pubmed/21792274
http://dx.doi.org/10.4137/EBO.S7122
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