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A Computational-Experimental Approach Identifies Mutations That Enhance Surface Expression of an Oseltamivir-Resistant Influenza Neuraminidase

The His274[Image: see text]Tyr (H274Y) oseltamivir (Tamiflu) resistance mutation causes a substantial decrease in the total levels of surface-expressed neuraminidase protein and activity in early isolates of human seasonal H1N1 influenza, and in the swine-origin pandemic H1N1. In seasonal H1N1, H274...

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Detalles Bibliográficos
Autores principales:	Bloom, Jesse D., Nayak, Jagannath S., Baltimore, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140507/ https://www.ncbi.nlm.nih.gov/pubmed/21799795 http://dx.doi.org/10.1371/journal.pone.0022201

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