Novel Lipophilic Acetohydroxamic Acid Derivatives Based on Conformationally Constrained Spiro Carbocyclic 2,6-Diketopiperazine Scaffolds with Potent Trypanocidal Activity

[Image: see text] We describe novel acetohydroxamic acid derivatives with potent activity against cultured bloodstream-form Trypanosoma brucei and selectivity indices of >1000. These analogues were derived from conformationally constrained, lipophilic, spiro carbocyclic 2,6-diketopiperazine (2,6-...

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Detalles Bibliográficos
Autores principales: Fytas, Christos, Zoidis, Grigoris, Tzoutzas, Nikolaos, Taylor, Martin C., Fytas, George, Kelly, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140774/
https://www.ncbi.nlm.nih.gov/pubmed/21542562
http://dx.doi.org/10.1021/jm200217m

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