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Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high...

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Autores principales: Nakajima, Hideki, Nakajima, Kimiko, Tarutani, Masahito, Morishige, Ryuji, Sano, Shigetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140918/
https://www.ncbi.nlm.nih.gov/pubmed/21681565
http://dx.doi.org/10.1007/s00403-011-1159-3
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author Nakajima, Hideki
Nakajima, Kimiko
Tarutani, Masahito
Morishige, Ryuji
Sano, Shigetoshi
author_facet Nakajima, Hideki
Nakajima, Kimiko
Tarutani, Masahito
Morishige, Ryuji
Sano, Shigetoshi
author_sort Nakajima, Hideki
collection PubMed
description Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI.
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spelling pubmed-31409182011-09-01 Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients Nakajima, Hideki Nakajima, Kimiko Tarutani, Masahito Morishige, Ryuji Sano, Shigetoshi Arch Dermatol Res Short Communication Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI. Springer-Verlag 2011-06-17 2011 /pmc/articles/PMC3140918/ /pubmed/21681565 http://dx.doi.org/10.1007/s00403-011-1159-3 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Short Communication
Nakajima, Hideki
Nakajima, Kimiko
Tarutani, Masahito
Morishige, Ryuji
Sano, Shigetoshi
Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title_full Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title_fullStr Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title_full_unstemmed Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title_short Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients
title_sort kinetics of circulating th17 cytokines and adipokines in psoriasis patients
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140918/
https://www.ncbi.nlm.nih.gov/pubmed/21681565
http://dx.doi.org/10.1007/s00403-011-1159-3
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