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NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report
Meckel’s diverticulum is the most frequent congenital malformation of the gastrointestinal tract. The most common ectopic tissue within a Meckel’s is heterotopic gastric mucosa, with bleeding being the most common presentation. However, perforation of a Meckel’s diverticulum is a rare presentation....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140930/ https://www.ncbi.nlm.nih.gov/pubmed/21811537 http://dx.doi.org/10.4021/jocmr504w |
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author | Brar, Avneet S. Gill, Richdeep S. Gill, Sumeet S. Wang, Haili |
author_facet | Brar, Avneet S. Gill, Richdeep S. Gill, Sumeet S. Wang, Haili |
author_sort | Brar, Avneet S. |
collection | PubMed |
description | Meckel’s diverticulum is the most frequent congenital malformation of the gastrointestinal tract. The most common ectopic tissue within a Meckel’s is heterotopic gastric mucosa, with bleeding being the most common presentation. However, perforation of a Meckel’s diverticulum is a rare presentation. NSAID-associated Meckel’s perforation has been suggested, however has not been documented in the literature. We present a case of a 17-year-old female with acute abdominal pain and tenderness following a 24-hour history of excessive ingestion of NSAIDS for pain related to tooth extraction. Chest radiograph demonstrated free intra-abdominal air and she was subsequently taken for exploratory laparotomy. A perforated Meckel’s diverticulum was isolated and resected. Though NSAID-associated bleeding of heterotopic gastric mucosa has been described, and perforation of the Meckel’s diverticulum has been suggested, no clear association between heterotopic gastric mucosa and perforation exists. On the other hand, the relationship between NSAIDS and gastric ulcer perforation is well documented. A similar mechanism may also play a role in NSAID-associated Meckel’s perforation. With how common NSAID use is, we believe it is important to document NSAID-associated perforation of a Meckel’s diverticulum. KEYWORDS: Meckel’s diverticulum; NSAIDS; Perforation; Heterotopic gastric mucosa |
format | Online Article Text |
id | pubmed-3140930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31409302011-08-02 NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report Brar, Avneet S. Gill, Richdeep S. Gill, Sumeet S. Wang, Haili J Clin Med Res Case Report Meckel’s diverticulum is the most frequent congenital malformation of the gastrointestinal tract. The most common ectopic tissue within a Meckel’s is heterotopic gastric mucosa, with bleeding being the most common presentation. However, perforation of a Meckel’s diverticulum is a rare presentation. NSAID-associated Meckel’s perforation has been suggested, however has not been documented in the literature. We present a case of a 17-year-old female with acute abdominal pain and tenderness following a 24-hour history of excessive ingestion of NSAIDS for pain related to tooth extraction. Chest radiograph demonstrated free intra-abdominal air and she was subsequently taken for exploratory laparotomy. A perforated Meckel’s diverticulum was isolated and resected. Though NSAID-associated bleeding of heterotopic gastric mucosa has been described, and perforation of the Meckel’s diverticulum has been suggested, no clear association between heterotopic gastric mucosa and perforation exists. On the other hand, the relationship between NSAIDS and gastric ulcer perforation is well documented. A similar mechanism may also play a role in NSAID-associated Meckel’s perforation. With how common NSAID use is, we believe it is important to document NSAID-associated perforation of a Meckel’s diverticulum. KEYWORDS: Meckel’s diverticulum; NSAIDS; Perforation; Heterotopic gastric mucosa Elmer Press 2011-04 2011-04-04 /pmc/articles/PMC3140930/ /pubmed/21811537 http://dx.doi.org/10.4021/jocmr504w Text en Copyright © 2011, Brar et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Brar, Avneet S. Gill, Richdeep S. Gill, Sumeet S. Wang, Haili NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title | NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title_full | NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title_fullStr | NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title_full_unstemmed | NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title_short | NSAID-Associated Perforation of a Meckel’s Diverticulum: A Case Report |
title_sort | nsaid-associated perforation of a meckel’s diverticulum: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140930/ https://www.ncbi.nlm.nih.gov/pubmed/21811537 http://dx.doi.org/10.4021/jocmr504w |
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