The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase

We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Na...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Cheng, Head-Gordon, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140967/
https://www.ncbi.nlm.nih.gov/pubmed/21814500
http://dx.doi.org/10.1371/journal.pcbi.1002082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140967/
https://www.ncbi.nlm.nih.gov/pubmed/21814500
http://dx.doi.org/10.1371/journal.pcbi.1002082

Ejemplares similares