Cargando…

The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase

We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Cheng, Head-Gordon, Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140967/ https://www.ncbi.nlm.nih.gov/pubmed/21814500 http://dx.doi.org/10.1371/journal.pcbi.1002082

Ejemplares similares

Mechanism of Auto-inhibition and Activation of Mec1(ATR) Checkpoint Kinase
por: Tannous, Elias A., et al.
Publicado: (2020)

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase
por: Yuk, Taewon, et al.
Publicado: (2018)

An auto-inhibited state of protein kinase G and implications for selective activation
por: Sharma, Rajesh, et al.
Publicado: (2022)

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
por: Kanagaki, Shuhei, et al.
Publicado: (2023)

Redox Regulation of the AMP-Activated Protein Kinase
por: Han, Yingying, et al.
Publicado: (2010)

Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivo and In Vitro
por: Feng, Qin, et al.
Publicado: (2013)

AMP-Activated Protein Kinase Signalling
por: Neumann, Dietbert, et al.
Publicado: (2019)

Liraglutide Inhibits Hepatitis C Virus Replication Through an AMP Activated Protein Kinase Dependent Mechanism
por: Lee, Mei-Yueh, et al.
Publicado: (2019)

Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase
por: Stone, Joshua D., et al.
Publicado: (2012)

Auto-phosphorylation Represses Protein Kinase R Activity
por: Wang, Die, et al.
Publicado: (2017)

Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel
por: Lanaspa, Miguel A., et al.
Publicado: (2015)

Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy
por: Lai, Hsin-Wu, et al.
Publicado: (2019)

ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise
por: Coccimiglio, Ian F., et al.
Publicado: (2020)

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity
por: Rubio, Teresa, et al.
Publicado: (2013)

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase
por: Ahmad, Bilal, et al.
Publicado: (2020)

8-Chloro-Cyclic AMP and Protein Kinase A I-Selective Cyclic AMP Analogs Inhibit Cancer Cell Growth through Different Mechanisms
por: Lucchi, Simona, et al.
Publicado: (2011)

AMP-activated protein kinase: An emerging target for ginseng
por: Jeong, Kyong Ju, et al.
Publicado: (2013)

Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
por: Zhou, Ben, et al.
Publicado: (2021)

Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase Is Not Involved in Hypothalamic AMP-Activated Protein Kinase Activation by Neuroglucopenia
por: Kawashima, Junji, et al.
Publicado: (2012)

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma
por: Cheng, Jidong, et al.
Publicado: (2014)

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
por: Heathcote, Helen R., et al.
Publicado: (2016)

Auto-thiophosphorylation activity of Src tyrosine kinase
por: Cabail, M. Zulema, et al.
Publicado: (2016)

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase
por: Ali, Nada, et al.
Publicado: (2016)

2-Octynoic Acid Inhibits Hepatitis C Virus Infection through Activation of AMP-Activated Protein Kinase
por: Yang, Darong, et al.
Publicado: (2013)

Role of AMP-Activated Protein Kinase in the Control of Appetite
por: Kola, B
Publicado: (2008)

AMP-activated protein kinase – not just an energy sensor
por: Hardie, David Grahame, et al.
Publicado: (2017)

Anti-inflammatory Property of AMP-activated Protein Kinase
por: Noor, Humaira B., et al.
Publicado: (2020)

Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle
por: Hunter, Roger W., et al.
Publicado: (2011)

Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin
por: Morrison, Kaitlin R., et al.
Publicado: (2023)

Regulation of AMP-activated protein kinase by natural and synthetic activators
por: Grahame Hardie, David
Publicado: (2016)

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo
por: Dong, Yunzhou, et al.
Publicado: (2010)

AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy
por: Lipovka, Yulia, et al.
Publicado: (2015)

West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development
por: Kobayashi, Shintaro, et al.
Publicado: (2020)

Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
por: Wu, Yong, et al.
Publicado: (2012)

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation
por: Xu, Miao, et al.
Publicado: (2014)

AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema
por: Cheng, Xiao-Yu, et al.
Publicado: (2017)

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
por: Ramamurthy, Santosh, et al.
Publicado: (2012)

Keeping the home fires burning(†): AMP-activated protein kinase
por: Hardie, D. Grahame
Publicado: (2018)

Research progress of AMP-activated protein kinase and cardiac aging
por: Qiu, Zhengqi, et al.
Publicado: (2023)

BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase
por: Lin, Wanhua, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_etdcqn9ptp15qc7tsu2sq55ti7