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Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tool...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140981/ https://www.ncbi.nlm.nih.gov/pubmed/21814514 http://dx.doi.org/10.1371/journal.pgen.1002110 |
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author | Landrette, Sean F. Xu, Tian |
author_facet | Landrette, Sean F. Xu, Tian |
author_sort | Landrette, Sean F. |
collection | PubMed |
description | With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tools such as somatic transgenesis, humanized rodents, and forward genetics. By combining these resources one is not only able to model disease for in vivo verification, but also to screen for mutations and pathways integral to disease progression and therapeutic intervention. In this review, we briefly outline the current advances in somatic mutagenesis and discuss how these new tools, especially the piggyBac transposon system, can be applied to decipher human biology and disease. |
format | Online Article Text |
id | pubmed-3140981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31409812011-08-03 Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes Landrette, Sean F. Xu, Tian PLoS Genet Review With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tools such as somatic transgenesis, humanized rodents, and forward genetics. By combining these resources one is not only able to model disease for in vivo verification, but also to screen for mutations and pathways integral to disease progression and therapeutic intervention. In this review, we briefly outline the current advances in somatic mutagenesis and discuss how these new tools, especially the piggyBac transposon system, can be applied to decipher human biology and disease. Public Library of Science 2011-07-21 /pmc/articles/PMC3140981/ /pubmed/21814514 http://dx.doi.org/10.1371/journal.pgen.1002110 Text en Landrette, Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Review Landrette, Sean F. Xu, Tian Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title | Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title_full | Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title_fullStr | Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title_full_unstemmed | Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title_short | Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes |
title_sort | somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140981/ https://www.ncbi.nlm.nih.gov/pubmed/21814514 http://dx.doi.org/10.1371/journal.pgen.1002110 |
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