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Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes

With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tool...

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Detalles Bibliográficos
Autores principales: Landrette, Sean F., Xu, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140981/
https://www.ncbi.nlm.nih.gov/pubmed/21814514
http://dx.doi.org/10.1371/journal.pgen.1002110
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author Landrette, Sean F.
Xu, Tian
author_facet Landrette, Sean F.
Xu, Tian
author_sort Landrette, Sean F.
collection PubMed
description With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tools such as somatic transgenesis, humanized rodents, and forward genetics. By combining these resources one is not only able to model disease for in vivo verification, but also to screen for mutations and pathways integral to disease progression and therapeutic intervention. In this review, we briefly outline the current advances in somatic mutagenesis and discuss how these new tools, especially the piggyBac transposon system, can be applied to decipher human biology and disease.
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spelling pubmed-31409812011-08-03 Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes Landrette, Sean F. Xu, Tian PLoS Genet Review With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations in vivo. Murine somatic mutagenesis is evolving to fulfill these needs with tools such as somatic transgenesis, humanized rodents, and forward genetics. By combining these resources one is not only able to model disease for in vivo verification, but also to screen for mutations and pathways integral to disease progression and therapeutic intervention. In this review, we briefly outline the current advances in somatic mutagenesis and discuss how these new tools, especially the piggyBac transposon system, can be applied to decipher human biology and disease. Public Library of Science 2011-07-21 /pmc/articles/PMC3140981/ /pubmed/21814514 http://dx.doi.org/10.1371/journal.pgen.1002110 Text en Landrette, Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Landrette, Sean F.
Xu, Tian
Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title_full Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title_fullStr Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title_full_unstemmed Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title_short Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes
title_sort somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140981/
https://www.ncbi.nlm.nih.gov/pubmed/21814514
http://dx.doi.org/10.1371/journal.pgen.1002110
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