Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(−8)) in GWAS were further g...

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Detalles Bibliográficos
Autores principales: Noguchi, Emiko, Sakamoto, Hiromi, Hirota, Tomomitsu, Ochiai, Kaori, Imoto, Yoshimasa, Sakashita, Masafumi, Kurosaka, Fumitake, Akasawa, Akira, Yoshihara, Shigemi, Kanno, Noriko, Yamada, Yumi, Shimojo, Naoki, Kohno, Yoichi, Suzuki, Yoichi, Kang, Mi-Jin, Kwon, Ji-Won, Hong, Soo-Jong, Inoue, Ken, Goto, Yu-ichi, Yamashita, Fumio, Asada, Takashi, Hirose, Hiroshi, Saito, Ikuo, Fujieda, Shigeharu, Hizawa, Nobuyuki, Sakamoto, Toru, Masuko, Hironori, Nakamura, Yusuke, Nomura, Ichiro, Tamari, Mayumi, Arinami, Tadao, Yoshida, Teruhiko, Saito, Hirohisa, Matsumoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140987/
https://www.ncbi.nlm.nih.gov/pubmed/21814517
http://dx.doi.org/10.1371/journal.pgen.1002170
Descripción
Sumario:Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(−8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P (combined) = 2.3×10(−10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(−10), OR = 1.52, and DPB1*0901: P = 2.0×10(−7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

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