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Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(−8)) in GWAS were further g...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140987/ https://www.ncbi.nlm.nih.gov/pubmed/21814517 http://dx.doi.org/10.1371/journal.pgen.1002170 |
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| author | Noguchi, Emiko Sakamoto, Hiromi Hirota, Tomomitsu Ochiai, Kaori Imoto, Yoshimasa Sakashita, Masafumi Kurosaka, Fumitake Akasawa, Akira Yoshihara, Shigemi Kanno, Noriko Yamada, Yumi Shimojo, Naoki Kohno, Yoichi Suzuki, Yoichi Kang, Mi-Jin Kwon, Ji-Won Hong, Soo-Jong Inoue, Ken Goto, Yu-ichi Yamashita, Fumio Asada, Takashi Hirose, Hiroshi Saito, Ikuo Fujieda, Shigeharu Hizawa, Nobuyuki Sakamoto, Toru Masuko, Hironori Nakamura, Yusuke Nomura, Ichiro Tamari, Mayumi Arinami, Tadao Yoshida, Teruhiko Saito, Hirohisa Matsumoto, Kenji |
| author_facet | Noguchi, Emiko Sakamoto, Hiromi Hirota, Tomomitsu Ochiai, Kaori Imoto, Yoshimasa Sakashita, Masafumi Kurosaka, Fumitake Akasawa, Akira Yoshihara, Shigemi Kanno, Noriko Yamada, Yumi Shimojo, Naoki Kohno, Yoichi Suzuki, Yoichi Kang, Mi-Jin Kwon, Ji-Won Hong, Soo-Jong Inoue, Ken Goto, Yu-ichi Yamashita, Fumio Asada, Takashi Hirose, Hiroshi Saito, Ikuo Fujieda, Shigeharu Hizawa, Nobuyuki Sakamoto, Toru Masuko, Hironori Nakamura, Yusuke Nomura, Ichiro Tamari, Mayumi Arinami, Tadao Yoshida, Teruhiko Saito, Hirohisa Matsumoto, Kenji |
| author_sort | Noguchi, Emiko |
| collection | PubMed |
| description | Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(−8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P (combined) = 2.3×10(−10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(−10), OR = 1.52, and DPB1*0901: P = 2.0×10(−7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations. |
| format | Online Article Text |
| id | pubmed-3140987 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-31409872011-08-03 Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations Noguchi, Emiko Sakamoto, Hiromi Hirota, Tomomitsu Ochiai, Kaori Imoto, Yoshimasa Sakashita, Masafumi Kurosaka, Fumitake Akasawa, Akira Yoshihara, Shigemi Kanno, Noriko Yamada, Yumi Shimojo, Naoki Kohno, Yoichi Suzuki, Yoichi Kang, Mi-Jin Kwon, Ji-Won Hong, Soo-Jong Inoue, Ken Goto, Yu-ichi Yamashita, Fumio Asada, Takashi Hirose, Hiroshi Saito, Ikuo Fujieda, Shigeharu Hizawa, Nobuyuki Sakamoto, Toru Masuko, Hironori Nakamura, Yusuke Nomura, Ichiro Tamari, Mayumi Arinami, Tadao Yoshida, Teruhiko Saito, Hirohisa Matsumoto, Kenji PLoS Genet Research Article Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(−8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P (combined) = 2.3×10(−10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(−10), OR = 1.52, and DPB1*0901: P = 2.0×10(−7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations. Public Library of Science 2011-07-21 /pmc/articles/PMC3140987/ /pubmed/21814517 http://dx.doi.org/10.1371/journal.pgen.1002170 Text en Noguchi et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Noguchi, Emiko Sakamoto, Hiromi Hirota, Tomomitsu Ochiai, Kaori Imoto, Yoshimasa Sakashita, Masafumi Kurosaka, Fumitake Akasawa, Akira Yoshihara, Shigemi Kanno, Noriko Yamada, Yumi Shimojo, Naoki Kohno, Yoichi Suzuki, Yoichi Kang, Mi-Jin Kwon, Ji-Won Hong, Soo-Jong Inoue, Ken Goto, Yu-ichi Yamashita, Fumio Asada, Takashi Hirose, Hiroshi Saito, Ikuo Fujieda, Shigeharu Hizawa, Nobuyuki Sakamoto, Toru Masuko, Hironori Nakamura, Yusuke Nomura, Ichiro Tamari, Mayumi Arinami, Tadao Yoshida, Teruhiko Saito, Hirohisa Matsumoto, Kenji Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title_full | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title_fullStr | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title_full_unstemmed | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title_short | Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations |
| title_sort | genome-wide association study identifies hla-dp as a susceptibility gene for pediatric asthma in asian populations |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140987/ https://www.ncbi.nlm.nih.gov/pubmed/21814517 http://dx.doi.org/10.1371/journal.pgen.1002170 |
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