Establishment of a Knock-In Mouse Model with the SLC26A4 c.919-2A>G Mutation and Characterization of Its Pathology

Recessive mutations in the SLC26A4 gene are a common cause of hereditary hearing impairment worldwide. Previous studies have demonstrated that different SLC26A4 mutations may have different pathogenetic mechanisms. In the present study, we established a knock-in mouse model (i.e., Slc26a4(tm1Dontuh/...

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Detalles Bibliográficos
Autores principales: Lu, Ying-Chang, Wu, Chen-Chi, Shen, Wen-Sheng, Yang, Ting-Hua, Yeh, Te-Huei, Chen, Pei-Jer, Yu, I-Shing, Lin, Shu-Wha, Wong, Jau-Min, Chang, Qing, Lin, Xi, Hsu, Chuan-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141011/
https://www.ncbi.nlm.nih.gov/pubmed/21811566
http://dx.doi.org/10.1371/journal.pone.0022150

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