Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search-Projection Pursuit Regression Method

The epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure–activity relationship (QSAR) study on the inhibitory activity of a series of quinazolin...

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Detalles Bibliográficos
Autores principales: Du, Hongying, Hu, Zhide, Bazzoli, Andrea, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141047/
https://www.ncbi.nlm.nih.gov/pubmed/21811593
http://dx.doi.org/10.1371/journal.pone.0022367

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