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Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency

During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3′ end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significance to the viral lifecycle has not been elucidated...

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Detalles Bibliográficos
Autores principales:	Richner, Justin M., Clyde, Karen, Pezda, Andrea C., Cheng, Benson Yee Hin, Wang, Tina, Kumar, G. Renuka, Covarrubias, Sergio, Coscoy, Laurent, Glaunsinger, Britt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141057/ https://www.ncbi.nlm.nih.gov/pubmed/21811408 http://dx.doi.org/10.1371/journal.ppat.1002150

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