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A Novel Redox Method for Rapid Production of Functional Bi-Specific Antibodies For Use in Early Pilot Studies

We demonstrate here a rapid alternative method for the production of functional bi-specific antibodies using the mild reducing agent 2-mercaptoethanesulfonic acid sodium salt (MESNA). Following reduction of a mixture of two monoclonal antibodies with MESNA to break inter heavy chain bonds, this solu...

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Detalles Bibliográficos
Autores principales:	Carlring, Jennifer, De Leenheer, Evy, Heath, Andrew William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141073/ https://www.ncbi.nlm.nih.gov/pubmed/21811628 http://dx.doi.org/10.1371/journal.pone.0022533

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