Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients

Inactivation of SMAD4 has been linked to several cancers and germline mutations cause juvenile polyposis (JP). We set out to identify the promoter(s) of SMAD4, evaluate their activity in cell lines and define possible transcription factor binding sites (TFBS). 5′-rapid amplification of cDNA ends (5′...

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Detalles Bibliográficos
Autores principales: Calva, Daniel, Dahdaleh, Fadi S., Woodfield, George, Weigel, Ronald J., Carr, Jennifer C., Chinnathambi, Sathivel, Howe, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141234/
https://www.ncbi.nlm.nih.gov/pubmed/21421563
http://dx.doi.org/10.1093/nar/gkr091

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