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Crystal structure of a KSHV–SOX–DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff

The early lytic phase of Kaposi’s sarcoma herpesvirus infection is characterized by viral replication and the global degradation (shutoff) of host mRNA. Key to both activities is the virally encoded alkaline exonuclease KSHV SOX. While the DNase activity of KSHV SOX is required for the resolution of...

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Detalles Bibliográficos
Autores principales:	Bagnéris, Claire, Briggs, Louise C., Savva, Renos, Ebrahimi, Bahram, Barrett, Tracey E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141240/ https://www.ncbi.nlm.nih.gov/pubmed/21421561 http://dx.doi.org/10.1093/nar/gkr111

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