Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers

Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers are synthetic sequence-selective DNA minor-groove cross-linking agents that possess two electrophilic imine moieties (or their equivalent) capable of forming covalent aminal linkages with guanine C2-NH(2) functionalities. The PBD dimer SJG-136, which ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahman, Khondaker M., James, Colin H., Thurston, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141243/
https://www.ncbi.nlm.nih.gov/pubmed/21427082
http://dx.doi.org/10.1093/nar/gkr122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141243/
https://www.ncbi.nlm.nih.gov/pubmed/21427082
http://dx.doi.org/10.1093/nar/gkr122

Ejemplares similares