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Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers
BACKGROUND: The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals. METHODS: Fourteen young, female, healthy never-smokers were recruited via public postings...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141370/ https://www.ncbi.nlm.nih.gov/pubmed/21711545 http://dx.doi.org/10.1186/1745-9974-7-3 |
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author | Ebihara, Satoru Ebihara, Takae Kanezaki, Masashi Gui, Peijun Yamasaki, Miyako Arai, Hiroyuki Kohzuki, Masahiro |
author_facet | Ebihara, Satoru Ebihara, Takae Kanezaki, Masashi Gui, Peijun Yamasaki, Miyako Arai, Hiroyuki Kohzuki, Masahiro |
author_sort | Ebihara, Satoru |
collection | PubMed |
description | BACKGROUND: The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals. METHODS: Fourteen young, female, healthy never-smokers were recruited via public postings. Twelve elderly female healthy never-smokers were recruited from a nursing home residence. The cough reflex threshold and the urge-to-cough were evaluated by inhalation of citric acid. The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C(2)) and five or more coughs (C(5)). The urge-to-cough was evaluated using a modified the Borg scale. RESULTS: There was no significant difference in the cough reflex threshold to citric acid between young and elderly subjects. The urge-to-cough scores at the concentration of C(2 )and C(5 )were significantly smaller in the elderly than young subjects. The urge-to-cough log-log slope in elderly subjects (0.73 ± 0.71 point · L/g) was significantly gentler than those of young subjects (1.35 ± 0.53 point · L/g, p < 0.01). There were no significant differences in the urge-to-cough threshold estimated between young and elderly subjects. CONCLUSIONS: The cough reflex threshold did not differ between young and elderly subjects whereas cognition of urge-to-cough was significantly decreased in elderly subjects in female never-smokers. Objective monitoring of cough might be important in the elderly people. |
format | Online Article Text |
id | pubmed-3141370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31413702011-07-23 Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers Ebihara, Satoru Ebihara, Takae Kanezaki, Masashi Gui, Peijun Yamasaki, Miyako Arai, Hiroyuki Kohzuki, Masahiro Cough Research BACKGROUND: The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals. METHODS: Fourteen young, female, healthy never-smokers were recruited via public postings. Twelve elderly female healthy never-smokers were recruited from a nursing home residence. The cough reflex threshold and the urge-to-cough were evaluated by inhalation of citric acid. The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs (C(2)) and five or more coughs (C(5)). The urge-to-cough was evaluated using a modified the Borg scale. RESULTS: There was no significant difference in the cough reflex threshold to citric acid between young and elderly subjects. The urge-to-cough scores at the concentration of C(2 )and C(5 )were significantly smaller in the elderly than young subjects. The urge-to-cough log-log slope in elderly subjects (0.73 ± 0.71 point · L/g) was significantly gentler than those of young subjects (1.35 ± 0.53 point · L/g, p < 0.01). There were no significant differences in the urge-to-cough threshold estimated between young and elderly subjects. CONCLUSIONS: The cough reflex threshold did not differ between young and elderly subjects whereas cognition of urge-to-cough was significantly decreased in elderly subjects in female never-smokers. Objective monitoring of cough might be important in the elderly people. BioMed Central 2011-06-28 /pmc/articles/PMC3141370/ /pubmed/21711545 http://dx.doi.org/10.1186/1745-9974-7-3 Text en Copyright ©2011 Ebihara et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ebihara, Satoru Ebihara, Takae Kanezaki, Masashi Gui, Peijun Yamasaki, Miyako Arai, Hiroyuki Kohzuki, Masahiro Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title | Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title_full | Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title_fullStr | Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title_full_unstemmed | Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title_short | Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
title_sort | aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141370/ https://www.ncbi.nlm.nih.gov/pubmed/21711545 http://dx.doi.org/10.1186/1745-9974-7-3 |
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