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Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome

The insulin/insulin-like growth factor-1 (IGF-1) pathway drives an evolutionarily conserved network that regulates lifespan and longevity. Individuals with Laron syndrome who carry mutations in the growth hormone receptor (GHR) gene that lead to severe congenital IGF-1 deficiency with decreased insu...

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Detalles Bibliográficos
Autores principales:	Melnik, Bodo C, John, Swen Malte, Schmitz, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141390/ https://www.ncbi.nlm.nih.gov/pubmed/21699736 http://dx.doi.org/10.1186/1743-7075-8-41

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