A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

BACKGROUND: Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs)...

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Detalles Bibliográficos
Autores principales: Ahn, Mi-Hyun, Park, Byung-Lae, Lee, Shin-Hwa, Park, Sung-Woo, Park, Jong-Sook, Kim, Do-Jin, Jang, An-Soo, Park, Jai-Soung, Shin, Hwa-Kyun, Uh, Soo-Taek, Kim, Yang-Ki, Kim, Young Whan, Han, Sung Koo, Jung, Ki-Suck, Lee, Kye Young, Jeong, Sung Hwan, Park, Jeong Woong, Choi, Byoung Whui, Park, In Won, Chung, Man Pyo, Shin, Hyoung Doo, Song, Jin Woo, Kim, Dong Soon, Park, Choon-Sik, Shim, Young-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141418/
https://www.ncbi.nlm.nih.gov/pubmed/21649933
http://dx.doi.org/10.1186/1465-9921-12-73

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