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Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

BACKGROUND: Several susceptibility genetic variants for autoimmune diseases have been identified. A subset of these polymorphisms displays an opposite risk profile in different autoimmune conditions. This observation open interesting questions on the evolutionary forces shaping the frequency of thes...

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Detalles Bibliográficos
Autores principales:	Cagliani, Rachele, Riva, Stefania, Pozzoli, Uberto, Fumagalli, Matteo, Comi, Giacomo P, Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141431/ https://www.ncbi.nlm.nih.gov/pubmed/21682861 http://dx.doi.org/10.1186/1471-2148-11-171

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