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Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet

BACKGROUND: Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrien...

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Autores principales: Xu, Jiqu, Zhou, Xiaoqi, Deng, Qianchun, Huang, Qingde, Yang, Jin'e, Huang, Fenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141551/
https://www.ncbi.nlm.nih.gov/pubmed/21663699
http://dx.doi.org/10.1186/1476-511X-10-96
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author Xu, Jiqu
Zhou, Xiaoqi
Deng, Qianchun
Huang, Qingde
Yang, Jin'e
Huang, Fenghong
author_facet Xu, Jiqu
Zhou, Xiaoqi
Deng, Qianchun
Huang, Qingde
Yang, Jin'e
Huang, Fenghong
author_sort Xu, Jiqu
collection PubMed
description BACKGROUND: Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet. METHODS: The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks. RESULTS: Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably. CONCLUSION: Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.
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spelling pubmed-31415512011-07-23 Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet Xu, Jiqu Zhou, Xiaoqi Deng, Qianchun Huang, Qingde Yang, Jin'e Huang, Fenghong Lipids Health Dis Research BACKGROUND: Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet. METHODS: The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks. RESULTS: Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably. CONCLUSION: Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation. BioMed Central 2011-06-13 /pmc/articles/PMC3141551/ /pubmed/21663699 http://dx.doi.org/10.1186/1476-511X-10-96 Text en Copyright ©2011 Xu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xu, Jiqu
Zhou, Xiaoqi
Deng, Qianchun
Huang, Qingde
Yang, Jin'e
Huang, Fenghong
Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title_full Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title_fullStr Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title_full_unstemmed Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title_short Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
title_sort rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141551/
https://www.ncbi.nlm.nih.gov/pubmed/21663699
http://dx.doi.org/10.1186/1476-511X-10-96
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