Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons

BACKGROUND: Though originally discovered in the immune system as an important mediator of inflammation, NF-κB has recently been shown to play key roles in the central nervous system, such as synaptogenesis, synaptic plasticity, and cognition. NF-κB activity is normally tightly regulated by its prima...

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Detalles Bibliográficos
Autores principales: Shim, David J, Yang, Li, Reed, J Graham, Noebels, Jeffrey L, Chiao, Paul J, Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141554/
https://www.ncbi.nlm.nih.gov/pubmed/21663635
http://dx.doi.org/10.1186/1750-1326-6-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141554/
https://www.ncbi.nlm.nih.gov/pubmed/21663635
http://dx.doi.org/10.1186/1750-1326-6-42

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