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FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

BACKGROUND: Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein (FAP), a serine protease selectively produced by tumor-associated fibroblasts in over 90% of epithelial tumors, was us...

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Detalles Bibliográficos
Autores principales:	Lee, Hyung-Ok, Mullins, Stefanie R, Franco-Barraza, Janusz, Valianou, Matthildi, Cukierman, Edna, Cheng, Jonathan D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141768/ https://www.ncbi.nlm.nih.gov/pubmed/21668992 http://dx.doi.org/10.1186/1471-2407-11-245

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