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PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB receptor tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or "addictive" to the Phosphatidylinositol-3-kinase (PI3K) pathway. HER2-...

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Detalles Bibliográficos
Autores principales:	Wang, Leiping, Zhang, Qunling, Zhang, Jian, Sun, Si, Guo, Haiyi, Jia, Zhen, Wang, Biyun, Shao, Zhimin, Wang, Zhonghua, Hu, Xichun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141770/ https://www.ncbi.nlm.nih.gov/pubmed/21676217 http://dx.doi.org/10.1186/1471-2407-11-248

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