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Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function

OBJECTIVE: This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). RESEARCH DESIGN AND METHODS: Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 yea...

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Autores principales: Andersson, Charlotte, Gislason, Gunnar H., Mérie, Charlotte, Mogensen, Ulrik M., Solomon, Scott D., Torp-Pedersen, Christian, Køber, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142062/
https://www.ncbi.nlm.nih.gov/pubmed/21715523
http://dx.doi.org/10.2337/dc11-0154
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author Andersson, Charlotte
Gislason, Gunnar H.
Mérie, Charlotte
Mogensen, Ulrik M.
Solomon, Scott D.
Torp-Pedersen, Christian
Køber, Lars
author_facet Andersson, Charlotte
Gislason, Gunnar H.
Mérie, Charlotte
Mogensen, Ulrik M.
Solomon, Scott D.
Torp-Pedersen, Christian
Køber, Lars
author_sort Andersson, Charlotte
collection PubMed
description OBJECTIVE: This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). RESEARCH DESIGN AND METHODS: Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 years. Multivariable Cox regression models were used to assess the risk of mortality associated with diabetes, and the importance of diabetes was examined independently within defined left ventricular ejection fraction (LVEF) subgroups. RESULTS: A total of 16,912 patients were included; 1,819 (11%) had diabetes. Diabetes and 15% unit depression in LVEF were of similar prognostic importance: hazard ratios (HRs) were 1.45 (95% CI 1.37–1.54) and 1.41 (1.37–1.45) for diabetes and LVEF depression, respectively. LVEF modified the outcomes associated with diabetes, with HRs being 1.29 (1.19–1.40) and 1.61 (1.49–1.74) in patients with LVEF <40% and LVEF ≥40%, respectively (P = 0.03). CONCLUSIONS: Patients within the higher LVEF categories have a greater mortality risk attributable to diabetes than patients within the lower LVEF categories.
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spelling pubmed-31420622012-08-01 Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function Andersson, Charlotte Gislason, Gunnar H. Mérie, Charlotte Mogensen, Ulrik M. Solomon, Scott D. Torp-Pedersen, Christian Køber, Lars Diabetes Care Original Research OBJECTIVE: This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). RESEARCH DESIGN AND METHODS: Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 years. Multivariable Cox regression models were used to assess the risk of mortality associated with diabetes, and the importance of diabetes was examined independently within defined left ventricular ejection fraction (LVEF) subgroups. RESULTS: A total of 16,912 patients were included; 1,819 (11%) had diabetes. Diabetes and 15% unit depression in LVEF were of similar prognostic importance: hazard ratios (HRs) were 1.45 (95% CI 1.37–1.54) and 1.41 (1.37–1.45) for diabetes and LVEF depression, respectively. LVEF modified the outcomes associated with diabetes, with HRs being 1.29 (1.19–1.40) and 1.61 (1.49–1.74) in patients with LVEF <40% and LVEF ≥40%, respectively (P = 0.03). CONCLUSIONS: Patients within the higher LVEF categories have a greater mortality risk attributable to diabetes than patients within the lower LVEF categories. American Diabetes Association 2011-08 2011-07-16 /pmc/articles/PMC3142062/ /pubmed/21715523 http://dx.doi.org/10.2337/dc11-0154 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Andersson, Charlotte
Gislason, Gunnar H.
Mérie, Charlotte
Mogensen, Ulrik M.
Solomon, Scott D.
Torp-Pedersen, Christian
Køber, Lars
Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title_full Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title_fullStr Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title_full_unstemmed Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title_short Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
title_sort long-term prognostic importance of diabetes after a myocardial infarction depends on left ventricular systolic function
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142062/
https://www.ncbi.nlm.nih.gov/pubmed/21715523
http://dx.doi.org/10.2337/dc11-0154
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