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Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

OBJECTIVE: Macrophage secretion of proinflammatory cytokines contributes to the pathogenesis of obesity-related insulin resistance. An important regulator of inflammation is the suppressor of cytokine signaling-1 (SOCS1), which inhibits the JAK-STAT and toll-like receptor-4 (TLR4) pathways. Despite...

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Detalles Bibliográficos
Autores principales:	Sachithanandan, Nirupa, Graham, Kate L., Galic, Sandra, Honeyman, Jane E., Fynch, Stacey L., Hewitt, Kimberly A., Steinberg, Gregory R., Kay, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142066/ https://www.ncbi.nlm.nih.gov/pubmed/21646388 http://dx.doi.org/10.2337/db11-0259

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