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Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes

OBJECTIVE: The mechanistic basis for the breakdown of T-cell tolerance in type 1 diabetes is unclear and could result from a gain of effector function and/or loss of regulatory function. In humans, the CD4+CD25+Foxp3+ T–cell compartment contains both effector and regulatory T cells, and it is not kn...

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Detalles Bibliográficos
Autores principales:	Hughson, Angela, Bromberg, Irina, Johnson, Barbara, Quataert, Sally, Jospe, Nicholas, Fowell, Deborah J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142074/ https://www.ncbi.nlm.nih.gov/pubmed/21715555 http://dx.doi.org/10.2337/db10-1661

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