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The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

OBJECTIVE: In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R(+/−)), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant heterodimers composed of one IGF-1Rαβ and one ins...

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Detalles Bibliográficos
Autores principales:	Abbas, Afroze, Imrie, Helen, Viswambharan, Hema, Sukumar, Piruthivi, Rajwani, Adil, Cubbon, Richard M., Gage, Matthew, Smith, Jessica, Galloway, Stacey, Yuldeshava, Nadira, Kahn, Matthew, Xuan, Shouhong, Grant, Peter J., Channon, Keith M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142083/ https://www.ncbi.nlm.nih.gov/pubmed/21677284 http://dx.doi.org/10.2337/db11-0197

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