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In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes

OBJECTIVE: Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes—a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in p...

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Detalles Bibliográficos
Autores principales:	Hodish, Israel, Absood, Afaf, Liu, Leanza, Liu, Ming, Haataja, Leena, Larkin, Dennis, Al-Khafaji, Ahmed, Zaki, Anthony, Arvan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142084/ https://www.ncbi.nlm.nih.gov/pubmed/21677281 http://dx.doi.org/10.2337/db10-1671

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