α5β1 Integrin-Mediated Adhesion to Fibronectin Is Required for Axis Elongation and Somitogenesis in Mice

The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins. Mice lacking a functional RGD motif in FN (FN(RGE/RGE)) or α5 integrin develop identical phenotypes characterized by embryonic lethality and a severely shortened posterior tr...

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Detalles Bibliográficos
Autores principales: Girós, Amparo, Grgur, Katja, Gossler, Achim, Costell, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142108/
https://www.ncbi.nlm.nih.gov/pubmed/21799763
http://dx.doi.org/10.1371/journal.pone.0022002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142108/
https://www.ncbi.nlm.nih.gov/pubmed/21799763
http://dx.doi.org/10.1371/journal.pone.0022002

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