Cargando…

Rivastigmine Lowers Aβ and Increases sAPPα Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons

Overproduction of amyloid-β (Aβ) protein in the brain has been hypothesized as the primary toxic insult that, via numerous mechanisms, produces cognitive deficits in Alzheimer's disease (AD). Cholinesterase inhibition is a primary strategy for treatment of AD, and specific compounds of this cla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bailey, Jason A., Ray, Balmiki, Greig, Nigel H., Lahiri, Debomoy K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142110/ https://www.ncbi.nlm.nih.gov/pubmed/21799757 http://dx.doi.org/10.1371/journal.pone.0021954

Ejemplares similares

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway
por: Lahiri, Debomoy K., et al.
Publicado: (2013)

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker
por: Ray, Balmiki, et al.
Publicado: (2011)

Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue
por: Ray, Balmiki, et al.
Publicado: (2016)

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease
por: Ray, Balmiki, et al.
Publicado: (2020)

Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease
por: Ray, Balmiki, et al.
Publicado: (2020)

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
por: Mulugeta, Ezra, et al.
Publicado: (2011)

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation
por: Tackenberg, Christian, et al.
Publicado: (2019)

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis
por: Li, Yazhou, et al.
Publicado: (2012)

GFAP expression and social deficits in transgenic mice overexpressing human sAPPα
por: Bailey, Antoinette R, et al.
Publicado: (2013)

Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research
por: Ray, Balmiki, et al.
Publicado: (2014)

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway
por: Milosch, N, et al.
Publicado: (2014)

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells
por: Tang, Shi-Yu, et al.
Publicado: (2020)

Secreted Amyloid Precursor Protein Alpha (sAPPα Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes
por: Peppercorn, Katie, et al.
Publicado: (2023)

Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation
por: Wang, Ruizhi, et al.
Publicado: (2022)

TreeSAPP: the Tree-based Sensitive and Accurate Phylogenetic Profiler
por: Morgan-Lang, Connor, et al.
Publicado: (2020)

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice
por: Morales-Corraliza, Jose, et al.
Publicado: (2009)

Regulation of the Soluble Amyloid Precursor Protein α (sAPPα) Levels by Acetylcholinesterase and Brain-Derived Neurotrophic Factor in Lung Cancer Cell Media
por: Al Khashali, Hind, et al.
Publicado: (2022)

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
por: Long, Justin M., et al.
Publicado: (2018)

Esophagectasis Related to Rivastigmine
por: Sasaki, Osamu, et al.
Publicado: (2019)

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
por: Tweedie, David, et al.
Publicado: (2012)

SAPP: functional genome annotation and analysis through a semantic framework using FAIR principles
por: Koehorst, Jasper J, et al.
Publicado: (2018)

Rivastigmine in the treatment of Alzheimer’s disease: an update
por: Onor, Maria Luisa, et al.
Publicado: (2007)

Rivastigmine in the treatment of patients with Alzheimer’s disease
por: Müller, Thomas
Publicado: (2007)

Acquired Localized Hypertrichosis Induced by Rivastigmine
por: Imbernón-Moya, Adrian, et al.
Publicado: (2016)

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis
por: Dostál, Jiří, et al.
Publicado: (2021)

An Atypical Cutaneous Reaction to Rivastigmine Transdermal Patch
por: Grieco, T., et al.
Publicado: (2011)

Rivastigmine for the treatment of dementia associated with Parkinson’s disease
por: Reingold, Jennifer L, et al.
Publicado: (2007)

Rivastigmine in Chinese patients with subcortical vascular dementia
por: Mok, Vincent, et al.
Publicado: (2007)

Effects of rivastigmin tartarat in the therapy of patients with schizophrenia
por: Djordjevic, Snezana, et al.
Publicado: (2010)

Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine
por: Gao, Guorui, et al.
Publicado: (2018)

Treatment of pediatric antimuscarinic delirium with oral rivastigmine
por: Yakey, Brandtly, et al.
Publicado: (2023)

Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP)
por: Gao, Tong, et al.
Publicado: (2018)

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures
por: Perez, Felipe P., et al.
Publicado: (2021)

Rivastigmine in Alzheimer’s disease: Cognitive function and quality of life
por: Annicchiarico, Roberta, et al.
Publicado: (2007)

Once-daily transdermal rivastigmine in the treatment of Alzheimer’s disease
por: Wentrup, Andreas, et al.
Publicado: (2009)

Efficacy of initial haemopurification strategy for acute paraquat poisoning in adults: study protocol for a randomised controlled trial (HeSAPP)
por: Cui, Jian-Wei, et al.
Publicado: (2018)

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
por: Chopra, Nipun, et al.
Publicado: (2020)

Development and Validation of a Spectrofluorimetric Method for the Estimation of Rivastigmine in Formulations
por: Kapil, R., et al.
Publicado: (2009)

Effect of Rivastigmine on Behavioral and Psychiatric Symptoms of Parkinson’s Disease Dementia
por: Oh, Yoon-Sang, et al.
Publicado: (2015)

Preparation and Characterization of Rivastigmine Transdermal Patch Based on Chitosan Microparticles
por: Sadeghi, Mohsen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vpph4taajedoflud9a0ej5l4sq