Rationally Designed Turn Promoting Mutation in the Amyloid-β Peptide Sequence Stabilizes Oligomers in Solution

Enhanced production of a 42-residue beta amyloid peptide (Aβ(42)) in affected parts of the brain has been suggested to be the main causative factor for the development of Alzheimer's Disease (AD). The severity of the disease depends not only on the amount of the peptide but also its conformatio...

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Detalles Bibliográficos
Autores principales: Rajadas, Jayakumar, Liu, Corey W., Novick, Paul, Kelley, Nicholas W., Inayathullah, Mohammed, LeMieux, Melburne C., Pande, Vijay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142112/
https://www.ncbi.nlm.nih.gov/pubmed/21799748
http://dx.doi.org/10.1371/journal.pone.0021776

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