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A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese

BACKGROUND: Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited. METHODS AND PRINCIPAL FINDINGS: A two-stage GWAS was performed in Han Chin...

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Autores principales: Cui, Bin, Zhu, Xiaolin, Xu, Min, Guo, Ting, Zhu, Dalong, Chen, Gang, Li, Xuejun, Xu, Lingyan, Bi, Yufang, Chen, Yuhong, Xu, Yu, Li, Xiaoying, Wang, Weiqing, Wang, Haifeng, Huang, Wei, Ning, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142153/
https://www.ncbi.nlm.nih.gov/pubmed/21799836
http://dx.doi.org/10.1371/journal.pone.0022353
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author Cui, Bin
Zhu, Xiaolin
Xu, Min
Guo, Ting
Zhu, Dalong
Chen, Gang
Li, Xuejun
Xu, Lingyan
Bi, Yufang
Chen, Yuhong
Xu, Yu
Li, Xiaoying
Wang, Weiqing
Wang, Haifeng
Huang, Wei
Ning, Guang
author_facet Cui, Bin
Zhu, Xiaolin
Xu, Min
Guo, Ting
Zhu, Dalong
Chen, Gang
Li, Xuejun
Xu, Lingyan
Bi, Yufang
Chen, Yuhong
Xu, Yu
Li, Xiaoying
Wang, Weiqing
Wang, Haifeng
Huang, Wei
Ning, Guang
author_sort Cui, Bin
collection PubMed
description BACKGROUND: Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited. METHODS AND PRINCIPAL FINDINGS: A two-stage GWAS was performed in Han Chinese from Mainland China. The discovery stage included 793 T2D cases and 806 healthy controls genotyped using Illumina Human 660- and 610-Quad BeadChips; and the replication stage included two independent case-control populations (a total of 4445 T2D cases and 4458 controls) genotyped using TaqMan assay. We validated the associations of KCNQ1 (rs163182, p = 2.085×10(−17), OR 1.28) and C2CD4A/B (rs1370176, p = 3.677×10(−4), OR 1.124; rs1436953, p = 7.753×10(−6), OR 1.141; rs7172432, p = 4.001×10(−5), OR 1.134) in Han Chinese. CONCLUSIONS AND SIGNIFICANCE: Our study represents the first GWAS of T2D with both discovery and replication sample sets recruited from Han Chinese men and women residing in Mainland China. We confirmed the associations of KCNQ1 and C2CD4A/B with T2D, with the latter for the first time being examined in Han Chinese. Arguably, eight more independent loci were replicated in our GWAS.
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spelling pubmed-31421532011-07-28 A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese Cui, Bin Zhu, Xiaolin Xu, Min Guo, Ting Zhu, Dalong Chen, Gang Li, Xuejun Xu, Lingyan Bi, Yufang Chen, Yuhong Xu, Yu Li, Xiaoying Wang, Weiqing Wang, Haifeng Huang, Wei Ning, Guang PLoS One Research Article BACKGROUND: Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited. METHODS AND PRINCIPAL FINDINGS: A two-stage GWAS was performed in Han Chinese from Mainland China. The discovery stage included 793 T2D cases and 806 healthy controls genotyped using Illumina Human 660- and 610-Quad BeadChips; and the replication stage included two independent case-control populations (a total of 4445 T2D cases and 4458 controls) genotyped using TaqMan assay. We validated the associations of KCNQ1 (rs163182, p = 2.085×10(−17), OR 1.28) and C2CD4A/B (rs1370176, p = 3.677×10(−4), OR 1.124; rs1436953, p = 7.753×10(−6), OR 1.141; rs7172432, p = 4.001×10(−5), OR 1.134) in Han Chinese. CONCLUSIONS AND SIGNIFICANCE: Our study represents the first GWAS of T2D with both discovery and replication sample sets recruited from Han Chinese men and women residing in Mainland China. We confirmed the associations of KCNQ1 and C2CD4A/B with T2D, with the latter for the first time being examined in Han Chinese. Arguably, eight more independent loci were replicated in our GWAS. Public Library of Science 2011-07-22 /pmc/articles/PMC3142153/ /pubmed/21799836 http://dx.doi.org/10.1371/journal.pone.0022353 Text en Cui et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cui, Bin
Zhu, Xiaolin
Xu, Min
Guo, Ting
Zhu, Dalong
Chen, Gang
Li, Xuejun
Xu, Lingyan
Bi, Yufang
Chen, Yuhong
Xu, Yu
Li, Xiaoying
Wang, Weiqing
Wang, Haifeng
Huang, Wei
Ning, Guang
A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title_full A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title_fullStr A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title_full_unstemmed A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title_short A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese
title_sort genome-wide association study confirms previously reported loci for type 2 diabetes in han chinese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142153/
https://www.ncbi.nlm.nih.gov/pubmed/21799836
http://dx.doi.org/10.1371/journal.pone.0022353
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