Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo

The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent central nervous system (CNS) disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focu...

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Autores principales: Marquet, Fabrice, Tung, Yao-Sheng, Teichert, Tobias, Ferrera, Vincent P., Konofagou, Elisa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142168/
https://www.ncbi.nlm.nih.gov/pubmed/21799913
http://dx.doi.org/10.1371/journal.pone.0022598
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author Marquet, Fabrice
Tung, Yao-Sheng
Teichert, Tobias
Ferrera, Vincent P.
Konofagou, Elisa E.
author_facet Marquet, Fabrice
Tung, Yao-Sheng
Teichert, Tobias
Ferrera, Vincent P.
Konofagou, Elisa E.
author_sort Marquet, Fabrice
collection PubMed
description The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent central nervous system (CNS) disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focused ultrasound (ME-FUS) has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. For the first time, the feasibility of transcranial ME-FUS BBB opening in non-human primates is demonstrated with subsequent BBB recovery. Sonications were combined with two different types of microbubbles (customized 4–5 µm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage.
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spelling pubmed-31421682011-07-28 Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo Marquet, Fabrice Tung, Yao-Sheng Teichert, Tobias Ferrera, Vincent P. Konofagou, Elisa E. PLoS One Research Article The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent central nervous system (CNS) disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focused ultrasound (ME-FUS) has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. For the first time, the feasibility of transcranial ME-FUS BBB opening in non-human primates is demonstrated with subsequent BBB recovery. Sonications were combined with two different types of microbubbles (customized 4–5 µm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage. Public Library of Science 2011-07-22 /pmc/articles/PMC3142168/ /pubmed/21799913 http://dx.doi.org/10.1371/journal.pone.0022598 Text en Marquet et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Marquet, Fabrice
Tung, Yao-Sheng
Teichert, Tobias
Ferrera, Vincent P.
Konofagou, Elisa E.
Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title_full Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title_fullStr Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title_full_unstemmed Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title_short Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo
title_sort noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142168/
https://www.ncbi.nlm.nih.gov/pubmed/21799913
http://dx.doi.org/10.1371/journal.pone.0022598
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