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A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-dependent luciferase production from the interferon β promoter in the absence of exogenously provided ligan...

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Detalles Bibliográficos
Autores principales:	Ranjith-Kumar, C. T., Wen, Yahong, Baxter, Nielson, Bhardwaj, Kanchan, Cheng Kao, C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142182/ https://www.ncbi.nlm.nih.gov/pubmed/21799903 http://dx.doi.org/10.1371/journal.pone.0022575

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