Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression

BACKGROUND: The aim of both classical (e.g. taxol) and targeted anti-mitotic agents (e.g. Aurora kinase inhibitors) is to disrupt the mitotic spindle. Such compounds are currently used in the clinic and/or are being tested in clinical trials for cancer treatment. We recently reported a new class of...

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Detalles Bibliográficos
Autores principales: Joshi, Sanket, Braithwaite, Antony W, Robinson, Phillip J, Chircop, Megan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142233/
https://www.ncbi.nlm.nih.gov/pubmed/21708043
http://dx.doi.org/10.1186/1476-4598-10-78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142233/
https://www.ncbi.nlm.nih.gov/pubmed/21708043
http://dx.doi.org/10.1186/1476-4598-10-78

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