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Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression

BACKGROUND: The aim of both classical (e.g. taxol) and targeted anti-mitotic agents (e.g. Aurora kinase inhibitors) is to disrupt the mitotic spindle. Such compounds are currently used in the clinic and/or are being tested in clinical trials for cancer treatment. We recently reported a new class of...

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Detalles Bibliográficos
Autores principales:	Joshi, Sanket, Braithwaite, Antony W, Robinson, Phillip J, Chircop, Megan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142233/ https://www.ncbi.nlm.nih.gov/pubmed/21708043 http://dx.doi.org/10.1186/1476-4598-10-78

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