Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans

Opioid neurotransmission has a key role in mediating reward-related behaviours. Opioid receptor (OR) antagonists, such as naltrexone (NTX), can attenuate the behaviour-reinforcing effects of primary (food) and secondary rewards. GSK1521498 is a novel OR ligand, which behaves as an inverse agonist at...

Descripción completa

Detalles Bibliográficos
Autores principales: Rabiner, E A, Beaver, J, Makwana, A, Searle, G, Long, C, Nathan, P J, Newbould, R D, Howard, J, Miller, S R, Bush, M A, Hill, S, Reiley, R, Passchier, J, Gunn, R N, Matthews, P M, Bullmore, E T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142667/
https://www.ncbi.nlm.nih.gov/pubmed/21502953
http://dx.doi.org/10.1038/mp.2011.29

Ejemplares similares

Ejemplares similares