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Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treate...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142701/ https://www.ncbi.nlm.nih.gov/pubmed/21792353 http://dx.doi.org/10.1155/2011/835932 |
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author | Švíglerová, Jitka Mudra, Jiří Tonar, Zbyněk Slavíková, Jana Kuncová, Jitka |
author_facet | Švíglerová, Jitka Mudra, Jiří Tonar, Zbyněk Slavíková, Jana Kuncová, Jitka |
author_sort | Švíglerová, Jitka |
collection | PubMed |
description | To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one. |
format | Online Article Text |
id | pubmed-3142701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31427012011-07-26 Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats Švíglerová, Jitka Mudra, Jiří Tonar, Zbyněk Slavíková, Jana Kuncová, Jitka Exp Diabetes Res Research Article To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one. Hindawi Publishing Corporation 2011 2011-07-17 /pmc/articles/PMC3142701/ /pubmed/21792353 http://dx.doi.org/10.1155/2011/835932 Text en Copyright © 2011 Jitka Švíglerová et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Švíglerová, Jitka Mudra, Jiří Tonar, Zbyněk Slavíková, Jana Kuncová, Jitka Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title | Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title_full | Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title_fullStr | Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title_full_unstemmed | Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title_short | Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats |
title_sort | alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142701/ https://www.ncbi.nlm.nih.gov/pubmed/21792353 http://dx.doi.org/10.1155/2011/835932 |
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