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Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats

To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treate...

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Autores principales: Švíglerová, Jitka, Mudra, Jiří, Tonar, Zbyněk, Slavíková, Jana, Kuncová, Jitka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142701/
https://www.ncbi.nlm.nih.gov/pubmed/21792353
http://dx.doi.org/10.1155/2011/835932
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author Švíglerová, Jitka
Mudra, Jiří
Tonar, Zbyněk
Slavíková, Jana
Kuncová, Jitka
author_facet Švíglerová, Jitka
Mudra, Jiří
Tonar, Zbyněk
Slavíková, Jana
Kuncová, Jitka
author_sort Švíglerová, Jitka
collection PubMed
description To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.
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spelling pubmed-31427012011-07-26 Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats Švíglerová, Jitka Mudra, Jiří Tonar, Zbyněk Slavíková, Jana Kuncová, Jitka Exp Diabetes Res Research Article To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one. Hindawi Publishing Corporation 2011 2011-07-17 /pmc/articles/PMC3142701/ /pubmed/21792353 http://dx.doi.org/10.1155/2011/835932 Text en Copyright © 2011 Jitka Švíglerová et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Švíglerová, Jitka
Mudra, Jiří
Tonar, Zbyněk
Slavíková, Jana
Kuncová, Jitka
Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title_full Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title_fullStr Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title_full_unstemmed Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title_short Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats
title_sort alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142701/
https://www.ncbi.nlm.nih.gov/pubmed/21792353
http://dx.doi.org/10.1155/2011/835932
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